From the East via PA 283:
follow I-283 North to I-83 South. Exit at the 2nd Street exit. Proceed straight onto 2nd Street to the 8th traffic light (State Street) and turn right onto State for the Cathedral.

From the North or South via I-81:
Exit at Cameron St/US Rt. 22 E to Harrisburg. (At Maclay Street [Farm Show Building], US-22 E becomes N. Cameron St./Rt. 230 E.) Continue on Cameron St. to Herr St. and turn right. Turn left onto N. Seventh St. Turn right onto Forster St. Turn left onto Third St. Turn right onto State Street for the Cathedral.

From the North via US Rt. 22:
Follow US Rt. 22 E to Harrisburg. (At Maclay Street [Farm Show Building], US-22 E becomes N. Cameron St./Rt. 230 E.) Continue on Cameron St. to Herr St. and turn right. Turn left onto N. Seventh St. Turn right onto Forster St. Turn left onto Third St. Turn right onto State Street for the Cathedral.

From the South via I-83:
Follow I-83 to Harrisburg. Exit at the 2nd Street exit. Proceed straight onto 2nd Street to the 8th traffic light (State Street) and turn right onto State for the Cathedral.

From the South via US Rt. 15:
Follow Rt. 581 to I-83 N to Harrisburg. Exit at the 2nd Street exit. Proceed straight onto 2nd Street to the 8th traffic light (State Street) and turn right onto State for the Cathedral.
 

Parking

Parking is available on Second, Third, or State Streets or in the South Street Parking Garage.  You may enter the garage by turning from State Street to Susquehanna Street or turning from Third Street to South Street.  On weekends, parking passes are available from the ushers after Mass.